IgE to cross-reactive carbohydrate determinants: Origins, functions, and confounding role in nPhl p 4-IgE assays
نویسندگان
چکیده
منابع مشابه
Inhibition of IgE binding to cross-reactive carbohydrate determinants enhances diagnostic selectivity
BACKGROUND Allergy diagnosis by determination of allergen-specific IgE is complicated by clinically irrelevant IgE, of which the most prominent example is IgE against cross-reactive carbohydrate determinants (CCDs) that occur on allergens from plants and insects. Therefore, CCDs cause numerous false-positive results. Inhibition of CCDs has been proposed as a remedy, but has not yet found its wa...
متن کاملInvolvement of cross-reactive carbohydrate determinants-specific IgE in pollen allergy testing
BACKGROUND Specific IgE antibodies against the low-molecular-weight carbohydrate antigen that does not bridge IgE molecules on mast cells are not associated with clinical symptoms. Cross reactivity can be determined in allergen-specific IgE detection assays when the carbohydrate structures between pollen allergens and plant derived food allergens are similar; in such cases, false positive resul...
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Background: The importance of peanut allergy has not been well recognized in Japanese society. IgE antibody to peanut can be, however, detected in patients without clinical peanut allergy. Methods: Clinical characteristics of 14 patients (aged 1―8 years) with peanut allergy were evaluated. IgE antibodies to peanut from patients with and without clinical peanut allergy were compared with those t...
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A relevant proportion of allergy diagnosis is accomplished by in vitro determination of specific immunglobulin E (sIgE) to extracts from suspected allergens. Such extracts inevitably contain glycoproteins, which may react with patients' IgE. In the case of plant and insect allergens, the relevant epitope structure is an α-1,3-fucose on the Asn-linked sugar residue of so-called N-glycans. Due to...
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Hyper IgE syndrome (Job’s syndrome) is a primary immunodeficiency disease with recurrent infections especially staphylococcal, coarse face, skeletal abnormality and significant increase in serum IgE level (IgE >2000IU/ml). We present a 16 years old boy admitted with chronic cough, dyspnea, eczema and pneumatocele. He had a history of chronic dermal infection since 1 month after birth. The dia...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2020
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2020.04.012